The painting depicts the Last Supper of Jesus with his twelve apostles. Jesus is seated at the center of the table, with his head bowed in prayer. The apostles are seated on either side of him, in various poses of shock, awe, and sadness. The table is set with a simple meal of bread and wine. The background of the painting is a dark, stormy sky, which suggests that the events of the Last Supper are taking place during a time of great turmoil and uncertainty.